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Statins as secondary preventives in patients with intracerebral hemorrhage

Signild Åsberg1, Bahman Farahmand2, Karin M Henriksson1

  • 1Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

International Journal of Stroke : Official Journal of the International Stroke Society
|November 29, 2018
PubMed

Insights

Statin therapy after intracerebral hemorrhage may reduce death risk without increasing recurrent hemorrhage. This study offers reassurance for using statins in stroke survivors, indicating potential safety and benefits in secondary stroke prevention.

Area of Science:

  • Neurology
  • Cardiology
  • Public Health

Background:

  • Statins are crucial for secondary stroke prevention.
  • Concerns exist regarding statin use increasing intracerebral hemorrhage (ICH) risk.
  • The safety of initiating or continuing statins post-ICH remains unclear.

Purpose of the Study:

  • To investigate the association between statin use and outcomes after a first intracerebral hemorrhage.
  • To assess risks of recurrent ICH, general stroke, and death in patients treated with statins post-ICH.

Main Methods:

  • Observational study of 6082 patients with first ICH (2004-2009).
  • Data sourced from the Swedish Stroke Register and national registers.
  • Propensity score and multivariable analysis used to adjust for confounding factors.

Main Results:

  • 18% of patients received statins at discharge.
  • Statin use was linked to a reduced risk of death (aHR 0.71).
  • No significant association found between statin use and recurrent ICH (aHR 0.82).

Conclusions:

  • Statin therapy appears safe for some patients post-intracerebral hemorrhage.
  • Statin use is associated with decreased mortality after ICH.
  • Evidence suggests statins do not elevate the risk of recurrent intracerebral hemorrhage.
Abstract

Keywords:
Epidemiologyintracerebral hemorrhagepreventionstatins

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