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Area of Science:

  • Urology
  • Addiction Medicine
  • Men's Health

Background:

  • Illicit ketamine abuse is a growing public health concern.
  • Ketamine use can lead to significant physical and psychological adverse effects.
  • The impact of ketamine abuse on male lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) requires further investigation.

Purpose of the Study:

  • To determine the prevalence of LUTS and ED among male ketamine abusers (KA).
  • To identify risk factors associated with LUTS and ED in this population.

Main Methods:

  • A structured questionnaire was administered to 1056 male ketamine abusers (street and hospital-based).
  • Data collected included demographics, ketamine use patterns, International Prostate Symptom Score (IPSS), Interstitial Cystitis Symptom and Problem Index (ICSI/ICPI), and International Index of Erectile Function (IIEF-5).
  • ED was defined as IIEF-5 ≤21; LUTS were defined as ICSI+ICPI ≥12.

Main Results:

  • ED was prevalent in 30.8% of KAs, with hospital-based KAs showing higher rates (69.6%) than street KAs (28.0%).
  • Risk factors for ED included age ≥30 years; abstinence ≥3 months was protective.
  • LUTS were also prevalent, with risk factors including age ≥30 years, duration of use ≥24 months, and co-use of other illicit drugs.

Conclusions:

  • Male ED and LUTS are frequently observed in ketamine abusers.
  • Street ketamine abuse should be considered in the differential diagnosis for young men presenting with ED and LUTS.
  • Early identification and intervention for ketamine abuse may help mitigate these urological complications.