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[Anti-mouse CD(52) antibody ameliorates colitis through suppressing Th1/17 mediated inflammation and promoting

J H Liu1, Y Li, W M Zhu1

  • 1Research Institute of General Surgery, Nanjing General Hospital of PLA, Medical School of Nanjing University, Nanjing 210002, China.

Zhonghua Nei Ke Za Zhi
|November 30, 2018
PubMed

In this study, we evaluated the therapeutic effects and possible mechanisms of anti-CD(5)2 treatment on interleukin-10 (IL-10) deficient mice. Anti-mouse CD(52) monoclonal antibody was administrated to C3H. IL-10(-/-)mice. The disease activity index, histological grading of colitis, serum Th1/17 related cytokines, percentage of CD(25+)Foxp3(+) T cells in colon as well as CD(25), Foxp3 gene expression were measured. Our data suggested that anti-CD(52) treatment inhibited colitis in C3H.IL-10(-/-)mice and it might be related to the suppression of Th1/17 related inflammation and the promotion of regulatory T cell differentiation.

Keywords:
Anti-CD(52) monoclonal antibodyColitisInterleukin-10 deficient miceRegulatory T cells

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