Temporary kidney dysfunction: supplementation with Meriva® in initial, transient kidney micro-macro albuminuria

Area of Science:

• Nephrology
• Nutritional Science
• Oxidative Stress Research

Background:

• Temporary kidney dysfunction (TKD) and elevated oxidative stress are concerns following drug use, clinical events, or dehydration.
• Albuminuria serves as a key marker for assessing TKD.

Purpose of the Study:

• To evaluate the efficacy of Meriva® (Curcumin Phytosome®) in subjects experiencing temporary kidney dysfunction (TKD) and increased oxidative stress.
• To assess the impact of Meriva® on albuminuria levels, oxidative stress markers, and overall well-being.

Main Methods:

• A 4-week registry study involving patients with TKD, divided into standard management (SM) or SM plus Meriva® (1.5 g/day).
• Patients were categorized based on macroalbuminuria or microalbuminuria levels.
• Blood pressure, blood, and urinary tests were conducted at baseline and follow-up.

Main Results:

• Meriva® supplementation led to a statistically significant decrease in albuminuria compared to controls (P<0.05).
• Subjects receiving Meriva® showed a significant reduction in oxidative stress levels.
• Normalized blood and urinary tests, controlled blood pressure, and decreased fatigue were observed in the supplemented group.

Conclusions:

• Meriva® (Curcumin Phytosome®) safely ameliorates albuminuria, a marker of TKD, and reduces oxidative stress.
• Further research is recommended to explore Meriva®'s effects in patients with more severe clinical conditions or risk factors.