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Thrombophilia Testing in High Pediatric Migraine Risk Children With Migraine

Yoel Levinsky1,2, Avraham Zeharia1,2, Joanne Yacobovich3,2

  • 1Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Journal of Child Neurology
|November 30, 2018
PubMed

Insights

Routine thrombophilia screening in pediatric migraine patients is not recommended. While some factors were common, elevated Lipoprotein(a) in children with migraine needs more research.

Area of Science:

  • Pediatric Neurology
  • Hematology
  • Genetics

Background:

  • Migraine is common in children.
  • Thrombophilia, a tendency to clot, may be linked to certain conditions.
  • Screening for thrombophilia in pediatric migraineurs is debated.

Purpose of the Study:

  • To determine the necessity of thrombophilia screening in children experiencing migraines.
  • To analyze the prevalence of thrombotic factors in pediatric migraineurs.

Main Methods:

  • Retrospective analysis of 45 pediatric migraine patients (aged 3-18) tested for thrombophilia.
  • Comparison of thrombotic factor rates with a healthy historical control group.
  • Analysis based on patient background and screening indications.

Main Results:

  • 42% of pediatric migraineurs had at least one positive thrombotic factor.
  • Thrombophilia risk was higher in patients with migraine aura.
  • Elevated Lipoprotein(a) was the most frequent abnormality (42%), significantly higher in migraineurs than controls.

Conclusions:

  • Comprehensive thrombophilia testing is not routinely justified for pediatric migraine patients.
  • The elevated prevalence of Lipoprotein(a) in children with migraine requires further investigation.

Keywords:
adolescentslipoprotein(a)migraine with auramigraine without aurapediatricthrombophilia testing

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