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Sensing acidosis: nociception or sngception?

Jiann-Her Lin1,2, Chih-Hsien Hung1,3,4, Der-Sheng Han5

  • 1Institute of Biomedical Sciences, Academia Sinica, 128 Academia Rd. Sec. 2, Taipei, 115, Taiwan.

Journal of Biomedical Science
|November 30, 2018
PubMed
Summary
This summary is machine-generated.

Researchers propose "sngception" to describe the somatosensory nervous system's response to tissue acidosis. This sensation, distinct from pain (nociception), can signal both pain relief (anti-nociception) and other sensory inputs.

Keywords:
ASIC3AcidosisNociceptionPainSngceptionSoreness

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Area of Science:

  • Neuroscience
  • Somatosensory System
  • Pain Research

Background:

  • Tissue acidosis sensing is a key somatosensory function, often linked to noxious stimuli.
  • Acid or soreness sensations are common in pain syndromes like fibromyalgia and muscle soreness.
  • Paradoxically, soreness can also indicate pain relief from therapies like acupuncture.

Purpose of the Study:

  • To introduce a new term, "sngception," for the somatosensory response to tissue acidosis.
  • To differentiate sngception from nociception (pain signaling).
  • To facilitate research into the molecular and neurobiological mechanisms of soreness sensation.

Main Methods:

  • Conceptual proposal of "sngception" based on existing observations.
  • Linguistic analysis: "Sng" is a Taiwanese word for soreness, mimicking vocalizations.
  • Distinguishing sngception's role from nociception in various pain and therapeutic contexts.

Main Results:

  • Soreness sensation is not exclusively nociceptive; it can be anti-nociceptive.
  • The proposed term "sngception" encompasses the somatosensory system's response to acidity.
  • Sngception represents a distinct sensory pathway from peripheral tissues to the central nervous system.

Conclusions:

  • Sngception is proposed as a specific somatosensory function for transmitting acid sensations.
  • This function can overlap with nociception but also mediate anti-nociception, proprioception, and pruriception.
  • The concept aids in understanding the complex roles of acidity sensation beyond pain.