Catering to chondrocytes

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A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
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A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

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Christopher H Evans1

  • 1Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN 55905, USA. evans.christopher@mayo.edu.

Science Translational Medicine
|November 30, 2018
PubMed

Abstract:

An innovative strategy for delivering drugs to chondrocytes in situ offers new avenues for treating osteoarthritis (Geiger et al, this issue).

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Growth of Cartilage and Bone Tissue01:27

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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