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Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice
08:03

Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice

Published on: April 15, 2014

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[Cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein (MOG) antibody]

Hiroshi Adachi1, Yukiko Ide1, Toshiyuki Takahashi2,3

  • 1Department of Neurology, Hyogo Prefectural Amagasaki General Medical Center.

Rinsho Shinkeigaku = Clinical Neurology
|November 30, 2018
PubMed

Insights

A young man experienced acute encephalitis, successfully treated with steroids. Myelin oligodendrocyte glycoprotein (MOG) antibody was identified as a potential cause, highlighting its role in cerebral cortical encephalitis.

Area of Science:

  • Neuroscience
  • Immunology
  • Neurology

Background:

  • Encephalitis presents with diverse neurological symptoms.
  • Cerebral cortical encephalitis often has an unknown etiology.
  • Autoimmune antibodies are implicated in some encephalitis cases.

Observation:

  • A 27-year-old man presented with acute encephalitis, including seizures and aphasia.
  • Cerebrospinal fluid analysis revealed elevated cells and protein.
  • Brain MRI showed left cerebral cortex FLAIR hyperintensities and swelling, with MRA revealing mild vasodilatation.

Findings:

  • The patient developed psychomotor excitement, responsive to high-dose steroid immunotherapy.
  • Serum testing confirmed positive anti-myelin oligodendrocyte glycoprotein (MOG) antibody.
  • Other autoimmune antibodies, including anti-aquaporin-4 and anti-NMDA receptor antibodies, were negative.

Implications:

  • This case suggests a potential role for anti-MOG antibodies in cerebral cortical encephalitis.
  • MOG antibody-associated encephalitis may present with symptoms mimicking other forms of encephalitis.
  • Prompt immunotherapy can lead to complete resolution and recovery.
Keywords:
cerebral cortexencephalitismyelin oligodendrocyte glycoprotein (MOG)seizure

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