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Updated: Feb 2, 2026

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
Septicemia, Meningitis and Bilateral Subdural Empyema in an Infant Caused by Staphylococcus aureus
1Dr Shameem Ahmed, Senior Consultant Neurosurgeon, Department of Neurosurgery, Apollo Hospitals (Unit: International Hospital), Guwahati , India.
Abstract:
Staphylococcus aureus is a global bacterial pathogen. It is an uncommon pathogen causing central nervous system infections, accounting for <1% cases of bacterial meningitis. Sinusitis, trauma and presence of an intracranial device have been reported as risk factors for developing meningitis and brain abscesses. A previously healthy 5-month-old female infant presented to a hospital in North-Eastern India in February 2018 with Staphylococcus aureus sepsis and meningitis and was subsequently detected to have developed bilateral subdural empyema on computed tomography scan of the brain. Burr hole evacuation procedure of subdural empyema was done on day-18 subsequent to which inflammatory markers and temperature gradually normalized. Prolonged course of intravenous antibiotics (5-weeks) and anticonvulsants were needed. This case highlights the importance of considering brain abscess and empyema in a child with meningitis whose temperature do not settle down after being treated appropriately and adequately with intravenous antibiotics and features such as seizures develop. It also reflects the challenges that may be faced by clinicians in resource-limited settings both during acute and follow-up stages.
Insights
Staphylococcus aureus can cause rare but serious central nervous system infections like meningitis and subdural empyema in infants. Early recognition and intervention are crucial, especially in resource-limited settings.
Area of Science:
- Infectious Diseases
- Pediatric Neurology
- Bacteriology
Background:
- Staphylococcus aureus is a significant global pathogen.
- Central nervous system infections are uncommon but severe manifestations of S. aureus.
- Risk factors include sinusitis, trauma, and intracranial devices.
Observation:
- A previously healthy infant presented with S. aureus sepsis and meningitis.
- Bilateral subdural empyema was diagnosed via CT scan.
- The infant underwent burr hole evacuation on day 18.
Findings:
- Post-procedure, inflammatory markers and temperature normalized.
- A 5-week course of intravenous antibiotics and anticonvulsants was administered.
- The case highlights diagnostic and management challenges in resource-limited areas.
Implications:
- Emphasizes considering brain abscess and empyema in pediatric meningitis with persistent fever or seizures.
- Underscores the importance of prompt diagnosis and management of S. aureus CNS infections.
- Highlights challenges in pediatric neurosurgical care in resource-limited settings.
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