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Depressive symptoms in Friedreich ataxia
Antonieta Nieto1, Atteneri Hernández-Torres1, Javier Pérez-Flores1
1Universidad de La Laguna, Spain.
International Journal of Clinical and Health Psychology : IJCHP
|November 30, 2018
Summary
Depression is common in Friedreich ataxia (FRDA), impacting cognition. Cognitive-affective symptoms were most strongly linked to slower reaction times in FRDA patients.
Area of Science:
- Neurology
- Psychiatry
- Clinical Psychology
Background:
- Friedreich ataxia (FRDA) is a disabling cerebellar degenerative disease.
- Depression is understudied in FRDA patients.
- Understanding depression's profile in FRDA is crucial.
Purpose of the Study:
- To investigate the prevalence and characteristics of depressive symptoms in FRDA.
- To examine the relationship between depression, demographic/disease variables, and cognitive processing speed in FRDA.
- To identify specific dimensions of depression impacting cognition.
Main Methods:
- 57 patients diagnosed with FRDA participated.
- Beck Depression Inventory-II (BDI) assessed depressive symptoms.
- Choice Reaction time task measured information processing speed.
Main Results:
- FRDA patients exhibited significantly higher mean BDI scores than the general population.
- 21% of FRDA patients reported moderate/severe depressive symptoms.
- Both cognitive-affective and somatic-motivational depression dimensions were elevated and predicted slower cognitive reaction times, with cognitive-affective symptoms explaining more variance.
Conclusions:
- Somatic-motivational and cognitive-affective depressive symptoms are frequent in FRDA.
- Depressive symptoms, particularly cognitive-affective ones, significantly influence cognitive processing speed in FRDA.
- Further research into managing depression in FRDA is warranted to potentially improve cognitive function.
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