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Aged Garlic and Cancer: A Systematic Review
Maryam Miraghajani1,2, Nahid Rafie3, Hossein Hajianfar4,3
1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
International Journal of Preventive Medicine
|November 30, 2018
Summary
Aged garlic consumption may be inversely associated with cancer incidence. While human study evidence is inconsistent, animal and laboratory results suggest potential anticancer properties, warranting further investigation.
Area of Science:
- Oncology
- Nutritional Science
- Pharmacology
Background:
- Cancer represents a significant global health burden, contributing to morbidity, mortality, and increased healthcare expenses.
- Aged garlic, a modified garlic preparation, has demonstrated potential anticancer effects, distinguishing it from raw garlic due to its milder taste and odor.
- Understanding the role of dietary components like aged garlic in cancer prevention and management is crucial for public health.
Purpose of the Study:
- To systematically review and summarize the existing scientific literature on the potential anticancer effects of aged garlic.
- To evaluate the evidence regarding aged garlic's impact on cancer incidence, prevention, and factors associated with malignancy.
- To assess the quality of studies and identify gaps in current research concerning aged garlic and cancer.
Main Methods:
- A comprehensive literature search was conducted across major electronic databases (MEDLINE, Web of Science, Cochrane Library, Google Scholar).
- Studies included human, animal, and in vitro cell studies examining the effects of aged garlic or its components on cancer outcomes.
- Systematic review methodology, adhering to PRISMA guidelines, was employed to select and evaluate 25 relevant articles from an initial pool of 304.
Main Results:
- The overall quality of human studies included in the review was assessed as good.
- Evidence from human studies regarding aged garlic's effect on cancer was inconsistent.
- Animal and laboratory studies predominantly showed consistent results, suggesting an inverse association between aged garlic intake and cancer.
Conclusions:
- While human data are mixed, preclinical evidence suggests aged garlic possesses anticancer properties.
- Further rigorous research is necessary to confirm these findings and determine aged garlic's role in cancer prevention programs.
- Incorporating aged garlic into a healthy diet may offer beneficial effects for cancer patients and prevention strategies.
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