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Related Experiment Video

Updated: Feb 2, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Template for MR Visualization and Needle Targeting.

Rui Li1, Sheng Xu2, Ivane Bakhutashvili2

  • 1School of Electrical and Computer Engineering, University of Georgia, Athens, GA, USA.

Annals of Biomedical Engineering
|November 30, 2018
PubMed
Summary
This summary is machine-generated.

A novel 3D-printed flexible template enhances magnetic resonance imaging (MRI)-guided procedures. This low-cost device, combined with OncoNav software, offers accurate needle targeting, comparable to robotic systems.

Keywords:
3D-printed templateMRI-guided procedureMRI-visible

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Area of Science:

  • Medical Devices
  • Image-Guided Therapy
  • Biomedical Engineering

Background:

  • Magnetic resonance imaging (MRI)-guided procedures require precise targeting.
  • Current methods can be time-consuming and lack optimal accuracy.
  • A need exists for improved, cost-effective targeting solutions.

Purpose of the Study:

  • To develop and evaluate a 3D-printed flexible template for enhanced MRI-guided procedures.
  • To assess the accuracy and efficiency of the template with the OncoNav software.
  • To provide a low-cost, disposable solution for accurate needle insertion.

Main Methods:

  • A flexible photopolymer resin was used to 3D-print a template with integrated contrast-filled containers and guide holes.
  • The OncoNav software was developed to assist in pre-selecting optimal needle insertion paths and depths.
  • A phantom study involving 13 needle insertions was conducted using CT scanning to evaluate accuracy.

Main Results:

  • The 3D-printed flexible template demonstrated accurate needle placement.
  • The mean total distance error was 2.7 mm, with a maximum error of 4.78 mm and a standard deviation of 1.1 mm.
  • The accuracy achieved was comparable to robot-assisted procedures.

Conclusions:

  • The developed 3D-printed flexible template and OncoNav software offer a promising solution for accurate MRI-guided needle targeting.
  • This disposable, low-cost device has the potential to improve efficiency and reduce costs in interventional procedures.
  • Further evaluation in clinical settings, such as prostate cancer biopsies, is warranted.