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Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Integration of Fiber Photometry and Focused Ultrasound Neuromodulation for Investigating Neural Modulation in Freely Moving Mice
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Focused Ultrasound for Neuromodulation.

David P Darrow1

  • 1Department of Neurosurgery, University of Minnesota, 420 Delaware St SE, MMC 96, Room D-429, Minneapolis, MN, 55455, USA. Darro015@umn.edu.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|November 30, 2018
PubMed
Summary

Focused ultrasound offers noninvasive neuromodulation for the brain, creating permanent lesions or reversible activity changes. Continued research is vital for its clinical translation.

Keywords:
Focused ultrasoundHIFULIFUneuromodulation

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Diagnostic ultrasound is a clinical imaging standard.
  • Focused ultrasound technology has advanced significantly for neurological applications.
  • Transcranial focused ultrasound can deliver energy precisely into the brain.

Purpose of the Study:

  • To explore the potential of focused ultrasound for noninvasive neuromodulation.
  • To highlight the technical advancements and challenges in applying focused ultrasound to the nervous system.
  • To discuss the underlying mechanisms and future clinical applications of focused ultrasound in neuroscience.

Main Methods:

  • Utilizing high-intensity focused ultrasound (HIFU) to create permanent brain lesions.
  • Employing low-intensity focused ultrasound (LIFU) for reversible neural excitation and inhibition.
  • Leveraging advanced imaging and monitoring for real-time feedback during focused ultrasound application.

Main Results:

  • HIFU demonstrates reliable permanent lesion creation in the brain.
  • LIFU shows potential for reversible modulation of neural activity.
  • Focused ultrasound offers precise, submillimeter targeting and real-time monitoring capabilities.

Conclusions:

  • Focused ultrasound presents a promising platform for noninvasive neuromodulation with potential for both permanent and reversible effects.
  • Despite technical complexities and elusive mechanisms, the technology's features support bench-to-bedside translation.
  • Continued scientific investment is warranted due to the bright future of focused ultrasound in neuroscience and clinical settings.