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Related Concept Videos

Types of Fever01:25

Types of Fever

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Series Resonance01:17

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The RLC circuit impedance is defined as the ratio of the supply voltage to the circuit current. Resonance in such a circuit occurs when the imaginary part of this impedance equals zero. This specific condition means that the inductive reactance is exactly equal to the capacitive reactance. The frequency at which this happens is known as the resonant frequency. Mathematically, the resonant frequency is inversely proportional to the square root of the product of the inductance (L) and capacitance...
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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
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Fever after meningococcal B immunisation: A case series.

Gillian Campbell1, Ruth M Bland1,2,3, Scott J Hendry1

  • 1Emergency Department, Royal Hospital for Children, Glasgow, United Kingdom.

Journal of Paediatrics and Child Health
|November 30, 2018
PubMed
Summary
This summary is machine-generated.

Fever in infants after meningococcal B vaccination is common, but serious bacterial infections are rare. Routine investigations are often unnecessary if the infant appears well; observation is recommended for concerning symptoms.

Keywords:
Bexserofeverimmunisationsinfantmeningococcal B

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Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Background:

  • Fever is a common post-vaccination reaction in infants.
  • Meningococcal B vaccination is crucial for preventing serious infections.
  • Distinguishing post-immunization fever from serious bacterial infection (SBI) can be challenging.

Purpose of the Study:

  • To describe clinical features and management of infants with fever post-meningococcal B vaccination.
  • To develop clinical guidance for managing these infants.
  • To assess the necessity of routine investigations for post-vaccination fever.

Main Methods:

  • Prospective case series conducted over 12 months in a tertiary pediatric hospital.
  • Included infants ≤3 months old with fever within 72 hours of their first meningococcal B immunization.
  • Data collected on clinical features, investigations, and outcomes.

Main Results:

  • 92 infants met inclusion criteria (0.78% of vaccinated).
  • Common symptoms included poor feeding, sleepiness, and irritability; 72% were hospitalized.
  • Only one confirmed bacterial infection; no missed SBIs in observed/discharged infants.

Conclusions:

  • Routine investigation for post-immunization fever is not warranted in well-appearing infants.
  • Observation is recommended for infants with associated symptoms or clinical concern.
  • Selective use of investigations, especially inflammatory markers, is advised; caution is needed for fever >48 hours post-vaccination.