Related Experiment Video
Updated: Feb 1, 2026

Assessing Disaster Resilience of Concrete with Titanium Dioxide Nanoparticles
Published on: November 14, 2025
Steady-State Electrochemiluminescence at Single Semiconductive Titanium Dioxide Nanoparticles for Local Sensing of
Chen Cui1, Ying Chen1, Dechen Jiang1
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering , Nanjing University , Nanjing , Jiangsu 210093 , China.
Abstract:
Obtaining steady-state bright electrochemiluminescence (ECL) at single nanoparticles is crucial but challenging for the realization of the single-nanoparticle electrochemical sensing of single cells. In this work, steady-state bright ECL is implemented at single semiconductive titanium dioxide (TiO2) nanoparticles for sensing the local efflux from single living cells. Oxygen vacancies on the surface of rutile TiO2 nanoparticles have a high affinity for hydrogen peroxides that are not easily passivated upon exposure to voltage. Therefore, the steady-state adsorption of hydrogen peroxide by the TiO2 nanoparticle surface permits the continuous electrochemical generation of superoxide and hydroxyl radicals by electrons and surface-trapped holes at the nanoparticles, resulting in constant ECL under physiological conditions. This steady-state luminescence during continuous imaging is correlated with the concentration of hydrogen peroxide, leading to the local ECL visualization of hydrogen peroxide efflux from single cells. The successful local ECL imaging demonstrated herein provides an unprecedented approach to enable subcellular electroanalysis using single nanoparticles.
Related Concept Videos
Cancers Originate from Somatic Mutations in a Single Cell
Load along a Single Axis
Consider a beam of length L subjected to a varying load, which is a combination of parabolic and trapezoidal load distribution along the x-axis. In this case, it is essential to determine the resultant loads, their locations, and...
Single Pipe Systems
In a Type I problem, fluid properties (density and viscosity), pipe characteristics (including diameter, length, and surface roughness), and the flow rate or average velocity are...
Steady State Concentration
Most drugs are administered in repeated doses at fixed intervals or through continuous...
Angular Momentum: Single Particle
Single-pass Transmembrane Proteins

