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Related Experiment Videos

Oscillatory potentials as a marker for dopaminergic disease.

M F Marmor1, P Hock, G Schechter

  • 1Department of Ophthalmology, Stanford University Medical Center, California.

Documenta Ophthalmologica. Advances in Ophthalmology
|July 1, 1988
PubMed
Summary

Schizophrenia patients and healthy volunteers showed similar electroretinogram oscillatory potentials. However, a D1 antagonist drug in rabbits suppressed specific oscillatory potentials, suggesting potential electrophysiologic markers for dopaminergic disease.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Psychiatry

Background:

  • Electrophysiologic correlates of dopaminergic diseases are sought.
  • Oscillatory potentials (OPs) of the electroretinogram (ERG) are investigated.
  • Schizophrenia is a complex psychiatric disorder with suspected dopaminergic involvement.

Purpose of the Study:

  • To identify electrophysiologic markers in the ERG related to dopaminergic dysfunction.
  • To compare OPs in schizophrenic patients and healthy controls.
  • To investigate the effects of D1 dopamine receptor modulation on ERG in rabbits.

Main Methods:

  • Measured ERG oscillatory potentials in 12 male schizophrenic and 9 male normal subjects.
  • Administered D1 agonist (SKF 38393) or D1 antagonist (SCH 23390) to rabbits.

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  • Analyzed ERG responses to single flash and 5-Hz flicker stimuli.

    • Main Results:

    • No significant differences in OPs were found between schizophrenic and normal human subjects.
    • D1 agonist administration in rabbits showed minimal ERG changes compared to controls.
    • D1 antagonist administration in rabbits led to b-wave diminution and suppression of the second OP, particularly with flicker stimuli.

    Conclusions:

    • Human ERG oscillatory potentials do not appear to differ between schizophrenic patients and healthy controls.
    • Dopamine D1 receptor antagonism in rabbits affects specific ERG oscillatory potentials.
    • These findings support further investigation of flicker ERG oscillatory potentials as potential biomarkers for dopaminergic dysfunction.