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Activating Autophagy by Aerobic Exercise in Mice
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Aerobic Exercise Improves Microvascular Function in Older Adults.

David M Hurley1, Ewan R Williams2, Jeff M Cross1

  • 1Department of Radiology, Michigan State University, East Lansing, MI.

Medicine and Science in Sports and Exercise
|November 30, 2018
PubMed
Summary
This summary is machine-generated.

Aerobic exercise training significantly improved leg microvascular function in older adults. This study demonstrates that regular physical activity can enhance vascular health in aging populations.

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Area of Science:

  • Physiology
  • Gerontology
  • Cardiovascular Health

Background:

  • Microvascular function declines with aging, disease, and inactivity.
  • Exercise is a known intervention to improve vascular health and potentially counteract age-related microvascular decline.

Purpose of the Study:

  • To evaluate the impact of a 12-week aerobic exercise program on peripheral microvascular function in sedentary older adults.

Main Methods:

  • A randomized controlled trial involving 23 sedentary older adults.
  • Intervention: 12 weeks of graded treadmill walking (40 min, 4 d/wk) at 70% heart rate reserve.
  • Measurements included blood oxygen level-dependent (BOLD) responses, popliteal artery blood flow, muscle oxidative capacity (kPCr), and peak oxygen consumption (V˙O2peak).

Main Results:

  • Significant improvements in peak postcontraction BOLD response (+33%) and popliteal artery blood flow (+39%) in the exercise group compared to controls.
  • Enhanced muscle oxidative capacity (+40%) and improved cardiorespiratory fitness (V˙O2peak +9%) were observed in the exercise group.
  • Hypertensive individuals in the exercise group showed a trend towards a blunted microvascular response.

Conclusions:

  • Moderate aerobic exercise effectively enhances leg microvascular function in older adults.
  • The findings support exercise as a strategy to improve vascular health in aging populations.