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Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3
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Darunavir Population Pharmacokinetic Model Based on HIV Outpatient Data
Alper Daskapan1, Quynh T D Tran1, Dario Cattaneo2
1Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Therapeutic Drug Monitoring
|November 30, 2018
Summary
A new population pharmacokinetic model for darunavir was developed and validated using real-world data. This model accurately predicts drug concentrations, aiding therapeutic drug monitoring for HIV-1 treatment.
Area of Science:
- Pharmacokinetics
- HIV-1 Treatment
- Drug Development
Background:
- Darunavir is a vital second-generation protease inhibitor for managing HIV-1 infection.
- Current treatment regimens necessitate effective therapeutic drug monitoring.
Purpose of the Study:
- To develop and validate a population pharmacokinetic model for darunavir.
- To assess the model's utility in daily clinical practice for HIV-1 management.
Main Methods:
- Utilized data from 368 patients across two international hospitals.
- Employed an iterative two-stage Bayesian approach for model development.
- Performed external validation using Passing-Bablok and Bland-Altman analyses.
Main Results:
- A robust 1-compartment pharmacokinetic model with first-order absorption and elimination was established.
- High correlation (r=0.97) observed between measured and predicted darunavir concentrations.
- 98.2% of predicted values fell within acceptable agreement limits, with minimal overestimation.
Conclusions:
- A validated population pharmacokinetic model for darunavir has been successfully developed.
- The model is suitable for supporting therapeutic drug monitoring in outpatient settings.
- This advancement can optimize HIV-1 treatment strategies.
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