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Updated: Feb 1, 2026

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System
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Advancements in MAPK signaling pathways and MAPK-targeted therapies for ameloblastoma: A review

Zhu You1,2,3, Shao-Peng Liu1,2, Jing Du1,4

  • 1Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, Shandong Province, China.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|November 30, 2018
PubMed

Insights

Mitogen-activated protein kinase (MAPK) pathways are crucial in ameloblastoma (AM) development. This review explores MAPK-targeted therapies for AM, discussing current treatments and future directions for improved efficacy and reduced side effects.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ameloblastoma (AM) development and prognosis are linked to various signal transduction pathways.
  • Mitogen-activated protein kinase (MAPK) signaling is a critical pathway involved in cellular processes and has been implicated in AM.

Purpose of the Study:

  • To review advancements in understanding MAPK signaling pathways in ameloblastoma.
  • To discuss current and potential MAPK-targeted therapies for AM, including their benefits and drawbacks.

Main Methods:

  • Literature review of studies on MAPK signaling in ameloblastoma.
  • Analysis of next-generation sequencing data, particularly focusing on BRAF V600E mutations and the Ras/Raf/MAPK pathway.
  • Evaluation of MAPK-targeted inhibitors and antibodies.

Main Results:

  • The MAPK signaling pathway, particularly through BRAF V600E activation, plays a significant role in ameloblastoma.
  • Next-generation sequencing has advanced the study of MAPK pathways in AM.
  • Existing MAPK-targeted therapies have both advantages and disadvantages.

Conclusions:

  • Targeted therapies focusing on the MAPK pathway show promise for ameloblastoma treatment.
  • Further research is needed to develop more efficient MAPK-targeted therapies with fewer side effects for AM.
Keywords:
BRafameloblastomamitogen-activated protein kinase signaling pathwaysodontogenic tumortargeted therapy

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