Related Experiment Video
Updated: Jul 7, 2026
09:41
Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
Published on: June 18, 2014
Summary
This study corrects a previous article. The correction pertains to information presented on page 164 in volume 6.
Area of Science:
- Scientific communication
- Publication ethics
Context:
- Correction of published scientific literature
- Ensuring accuracy in research records
Purpose:
- To amend a specific error in a published article
- Maintain the integrity of scientific documentation
Summary:
- A correction is issued for an article published in volume 6
- The specific location of the error is page 164
Impact:
- Restores accuracy to the scientific record
- Upholds standards of scholarly publishing
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01:43Proofreading
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01:36Mismatch Repair
Overview
01:43Proofreading
Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
01:31Proofreading
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Errors During Replication are Corrected by the DNA Polymerase Enzyme
01:20Mismatch Repair
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
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