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Paul M Bakaki1, Alexis Horace2, Neal Dawson1,3,4

  • 1Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America.

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Summary
This summary is machine-generated.

Pediatric polypharmacy lacks consistent definitions, creating challenges for research and clinical practice. This review proposes a standardized definition: "the prescription or consumption of two or more distinct medications for at least one day".

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Area of Science:

  • Pediatric pharmacology
  • Clinical pharmacy
  • Health services research

Background:

  • The lack of consensus on pediatric polypharmacy definitions complicates research and clinical application.
  • Standardized terminology is crucial for accurate data interpretation and comparative studies in pediatric medication use.

Purpose of the Study:

  • To conduct a scoping review to identify and describe the various definitions and terminology used for pediatric polypharmacy.
  • To propose a standardized definition for pediatric polypharmacy to enhance consistency in research and clinical practice.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (Medline, PubMed, EMBASE, CINAHL, PsycINFO, Cochrane CENTRAL, Web of Science).
  • English language articles focusing on
  • Data extraction included study characteristics, polypharmacy terms, and definitions, followed by synthesis based on disease conditions.

Main Results:

  • Out of 4,398 titles reviewed, 363 studies were included.
  • Over 81% of studies defined pediatric polypharmacy as two or more medications or therapeutic classes.
  • Common definitions involved concurrent medications for at least one day, 31 days, or sequential medications over one year; terms like polypharmacy and polytherapy were frequently used.

Conclusions:

  • Existing definitions of pediatric polypharmacy vary, particularly regarding the number of medications, concurrency, and duration.
  • Recommendations include specifying these parameters in future studies and adopting the proposed definition: 'the prescription or consumption of two or more distinct medications for at least one day'.
  • Consistent use of the term 'polypharmacy' in keywords and definitions is encouraged for improved discoverability.