Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleosome02:33

The Nucleosome

18.8K
DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
18.8K
The Nucleosome02:33

The Nucleosome

5.1K
5.1K
The Nucleosome01:19

The Nucleosome

4.0K
Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
4.0K
Nucleosome Remodeling02:54

Nucleosome Remodeling

11.1K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.1K
The Nucleosome Core Particle02:10

The Nucleosome Core Particle

14.4K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
14.4K
The Nucleosome Core Particle01:12

The Nucleosome Core Particle

2.4K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The ga3ox1b mutation reveals the crosstalk between gibberellin and other phytohormones in controlling the growth and development of female flowers in Cucurbita pepo.

Journal of experimental botany·2026
Same author

Life's Essential 8 and Risk of Severe COVID-19 Among Adults Without Clinical Cardiovascular Disease: The C4R Study.

Journal of the American Heart Association·2026
Same author

Sequence bias in chromatin fragmentation leads to misinterpretation of protein-DNA interactions in vivo.

Genome biology·2026
Same author

Associations between symptoms of depression and anxiety with left ventricular hypertrophy among Hispanic/Latino participants of the Hispanic Community Health Study/Study of Latinos.

medRxiv : the preprint server for health sciences·2026
Same author

How Accurate Are Population Predictions? Wind Farms and Egyptian Vultures as a Case Study.

Biology·2025
Same author

Continuous Production of Methyl Lactate from Hemicellulosic Sugars: Identifying and Sorting out Sn-USY-Based Catalyst Deactivation.

ACS sustainable chemistry & engineering·2025

Related Experiment Video

Updated: Feb 1, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K

Genome-wide search of nucleosome patterns using visual analytics.

Rodrigo Santamaría1, Roberto Therón1, Laura Durán2

  • 1Departmento de Informática y Automática, Universidad de Salamanca, Salamanca, Spain.

Bioinformatics (Oxford, England)
|November 30, 2018
PubMed
Summary
This summary is machine-generated.

We developed a fast nucleosome pattern search method using the Burrows-Wheeler transform (BWT). This approach, integrated into the Nucleosee browser, enhances pattern discovery in genomic coverage data.

More Related Videos

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
14:26

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

Published on: April 4, 2016

25.9K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.2K

Related Experiment Videos

Last Updated: Feb 1, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

5.4K
Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
14:26

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

Published on: April 4, 2016

25.9K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.2K

Area of Science:

  • Bioinformatics
  • Genomics
  • Computational Biology

Background:

  • The Burrows-Wheeler transform (BWT) is a key algorithm for efficient high-throughput sequence alignment.
  • BWT applications extend to other bioinformatics domains, including pattern searching on diverse data sources.

Purpose of the Study:

  • To introduce a novel nucleosome pattern search method leveraging BWT.
  • To develop an interactive visual tool, Nucleosee, for contextualizing and analyzing BWT search results.

Main Methods:

  • Nucleosomal occupancy data is transformed into a sequence-like format.
  • BWT algorithms are applied to this sequence data for pattern identification.
  • The Nucleosee browser provides an interactive platform for visualizing and exploring search outcomes.

Main Results:

  • The presented method enables rapid and flexible searching of nucleosome patterns.
  • Nucleosee enhances the interpretability of BWT searches through visual context.
  • The approach facilitates broad and interactive data exploration.

Conclusions:

  • This integrated method offers a powerful and efficient solution for analyzing nucleosome occupancy patterns.
  • The Nucleosee tool supports visual discourse analysis of complex genomic data.
  • The developed algorithm and browser are readily accessible for research and testing.