Testing the Medina embolization device in experimental aneurysms.

Area of Science:

• Endovascular neurosurgery
• Medical device innovation
• Aneurysm treatment

Background:

• The Medina embolization device (MED) is a novel endovascular device for aneurysm occlusion.
• Optimal use of MEDs for complex aneurysms, alone or with coils, is not established.

Purpose of the Study:

• To evaluate the efficacy of the Medina embolization device (MED) alone and in combination with platinum coils for treating experimental aneurysms.
• To compare these treatments against standard platinum coiling.

Main Methods:

• 31 canines underwent creation of 52 aneurysms, with 48 remaining patent.
• Treatments included MEDs alone (n=16), MEDs plus coils (n=16), and coils alone (n=16).
• Angiographic and histopathological analyses were performed immediately post-treatment and at 3 months.

Main Results:

• Initially, coils alone achieved higher occlusion rates (62.5%) compared to MEDs alone (12.5%) or MEDs plus coils (18.7%).
• At 3 months, occlusion rates were similar across groups: MEDs alone (68.7%), MEDs plus coils (56.2%), and coils alone (50%).
• Neointimal closure scores were comparable among the three treatment groups at 3 months.

Conclusions:

• Endovascular treatment with MEDs, with or without coils, resulted in comparable angiographic occlusion and neointimal closure at 3 months to standard platinum coiling.
• The study suggests MEDs are a viable alternative for aneurysm treatment, with outcomes similar to traditional methods at medium-term follow-up.