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Cutaneous Involvement of Hematologic Malignancies.

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  • 1Department of Hematology and Oncology, Dana-Farber Cancer Institute at St Elizabeth's Medical Center, 736 Cambridge Street, Brighton, MA 02135, USA.

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|December 1, 2018
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Summary

This review covers skin manifestations of hematologic cancers, focusing on secondary cutaneous lymphomas and histiocyte disorders like Langerhans cell histiocytosis. It details their histology, causes, symptoms, and treatments.

Keywords:
Histiocyte disordersLangerhans cell histiocytosis (LCH)Rosai-Dorfman disease (RDD)Secondary cutaneous lymphoma

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Hematologic malignancies can present with diverse cutaneous manifestations.
  • Secondary cutaneous lymphomas arise from systemic lymphoma infiltration.
  • Histiocytic disorders frequently involve the skin.

Purpose of the Study:

  • To review secondary cutaneous lymphomas.
  • To discuss cutaneous manifestations of histiocyte disorders, specifically Langerhans cell histiocytosis and Rosai-Dorfman disease.
  • To provide comprehensive information on these conditions.

Main Methods:

  • Literature review of secondary cutaneous lymphomas.
  • Literature review of cutaneous manifestations of histiocyte disorders.
  • Emphasis on histology, pathophysiology, clinical presentation, prognosis, and treatment.

Main Results:

  • Secondary cutaneous lymphomas are skin lesions from systemic lymphoma infiltration.
  • Langerhans cell histiocytosis and Rosai-Dorfman disease are key histiocytic disorders with skin involvement.
  • Detailed descriptions of disease characteristics and management are provided.

Conclusions:

  • Understanding cutaneous manifestations is crucial for diagnosing hematologic malignancies.
  • Secondary cutaneous lymphomas and histiocytic disorders require specific diagnostic and therapeutic approaches.
  • This review offers a consolidated resource for clinicians managing these conditions.