Related Experiment Video
Updated: Feb 1, 2026

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
Published on: February 10, 2013
Persistent but reversible advanced atrio-ventricular block in a heart transplant man induced by dobutamine stress
M Kyriakopoulou1, D C Mirica1, R Casado-Arroyo1
1Cardiology Department, Université Libre de Bruxelles, Hôpital Erasme, Route de Lennik 808, 1070, Bruxelles, Belgium.
Insights
Dobutamine stress echocardiography rarely causes heart block. This case highlights a heart transplant patient who developed persistent advanced atrioventricular block requiring pacemaker implantation after the procedure.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
Background:
- Dobutamine stress echocardiography (DSE) is a common diagnostic tool.
- Transient atrioventricular (AV) block is a rare complication of DSE.
Observation:
- A heart transplant patient with high cardiovascular risk underwent DSE.
- The patient developed symptomatic advanced AV block during the procedure.
Findings:
- The AV block persisted even after dobutamine administration was stopped.
- Pacemaker implantation was necessary due to the persistent high-grade AV block.
Implications:
- This case represents the first reported instance of persistent high-grade AV block induced by DSE in a heart transplant recipient.
- Clinicians should be vigilant for prolonged AV block in high-risk patients, especially heart transplant recipients, undergoing DSE.
Abstract:
Dobutamine when used for stress echocardiography (DSE), it rarely causes transient atrio-ventricular (AV) block. We report a heart transplant patient with high cardiovascular risk who developed symptomatic advanced AV block during DSE which persisted after termination of dobutamine administration, necessitating pacemaker implantation. To our knowledge, this is the first published case of persistent high grade AV block in a heart transplant patient induced by DSE.
Related Concept Videos
Anatomy of the Heart
Block Diagram Reduction
The first step in this process is the identification and relocation of a branch point. A branch point, where a...
Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
Reversible and Irreversible Processes
Diode: Reverse bias
Elements of Block Diagrams
A block diagram typically includes essential elements such as comparators, blocks, and feedback loops. Each of these elements...

