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Updated: Feb 1, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Severe hypercalcemia from multiple myeloma as an acquired cause of short QT
Yingwei Liu1, Andrés Ricardo Pérez-Riera2, Raimundo Barbosa-Barros3
1Division of Cardiology, Kingston Health Science Center, Queen's University, Kingston, Ontario, Canada.
Abstract:
An otherwise healthy 64-year-old man with recently diagnosed multiple myeloma was admitted to hospital with hypercalcemia and renal failure. Despite his electrocardiogram showing short QT/QTc intervals, he was admitted without cardiac monitoring. He died suddenly a few hours later, likely from a fatal arrhythmia. This case illustrates that pronounced QT shortening from hypercalcemia is an underappreciated malignant finding that can portend a significant risk for arrhythmia and sudden cardiac death. In addition, we also discuss the causes of hypercalcemia associated short QT/QTc intervals and its ECG features.
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