Brugada phenocopy associated with left ventricular aneurysm.

Area of Science:

• Cardiology
• Clinical Electrophysiology
• Medical Diagnostics

Background:

• Brugada phenocopies (BrP) present electrocardiogram (ECG) patterns indistinguishable from Brugada syndrome.
• These ECG abnormalities arise from diverse underlying clinical conditions, not genetic mutations typical of Brugada syndrome.
• Identifying the cause of BrP is crucial for appropriate patient management and risk stratification.

Observation:

• A 41-year-old male patient presented with ECG findings consistent with Brugada phenocopies.
• The patient had a history of chronic coronary artery disease.
• Further investigation revealed a left ventricular aneurysm as the likely cause of the observed ECG abnormalities.

Findings:

• The left ventricular aneurysm was identified as the specific condition inducing the Brugada phenocopy in this patient.
• This case demonstrates a novel association between left ventricular aneurysm and BrP.
• The ECG findings normalized after addressing the underlying cardiac pathology, confirming the phenocopy nature.

Implications:

• Left ventricular aneurysms should be considered in the differential diagnosis of Brugada phenocopies, particularly in patients with coronary artery disease.
• This finding expands the spectrum of conditions that can mimic Brugada syndrome.
• Accurate diagnosis of BrP etiology is essential for guiding treatment and preventing misdiagnosis of inherited Brugada syndrome.