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Reference values of ECG parameters derived from 906 echocardiographically confirmed healthy Indian children: A

Snehal Kulkarni1, Khushboo Chaudhari1, Pooja Hingorani1

  • 1Cardiac Safety Services, IQVIA, Mumbai, India.

Journal of Electrocardiology
|December 1, 2018
PubMed

Insights

This study established normal electrocardiogram (ECG) reference ranges for Indian children aged 5-15. The findings indicate that these pediatric ECG parameters are comparable across different ethnic groups.

Area of Science:

  • Pediatric Cardiology
  • Clinical Electrophysiology
  • Biometrics

Background:

  • Limited published data exists on electrocardiogram (ECG) reference ranges in children.
  • Previous studies suggest potential ethnic variations in pediatric ECG parameters.

Purpose of the Study:

  • To define age-specific normal limits for key ECG parameters in healthy Indian children.
  • To investigate potential sex-based differences in ECG intervals.
  • To compare findings with existing international pediatric ECG reference ranges.

Main Methods:

  • Analysis of digital 12-lead ECGs from 906 healthy Indian children (aged 5-15 years).
  • Measurement of PR interval, QRS duration, and corrected QT (QTc) intervals using superimposed median beats.
  • Determination of age-wise normal limits including median, 2nd, and 98th percentiles.

Main Results:

  • Heart rate and QTcB interval showed age-related changes, with QTcB decreasing after age 12 in boys.
  • PR interval and QRS duration increased with age.
  • Prevalence of "Juvenile T wave pattern" and RV dominance in lead V1 decreased with age.

Conclusions:

  • Established reference ranges for ECG parameters in Indian children aged 5-15 years.
  • Findings suggest similarity of these reference ranges to those reported in other ethnic populations.
  • Provides valuable data for pediatric cardiology interpretation in the Indian subcontinent.
Abstract

Keywords:
ChildrenGenderJuvenile T wavesNormal rangeRight ventricular dominance

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