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Methylene chloride poisoning: a paradigmatic review
1Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health Baltimore, MD.
The Journal of Emergency Medicine
|May 1, 1988
Summary
Methylene chloride (MC) poisoning cases are rising, often acute and domestic. MC
Area of Science:
- Toxicology
- Environmental Health
- Occupational Medicine
Background:
- Reports of methylene chloride (MC) toxicity have increased recently.
- Domestic poisonings are common, with central nervous system effects being prevalent.
- MC metabolism paradoxically produces toxic carbon monoxide.
Purpose of the Study:
- To review clinical experiences with methylene chloride poisoning.
- To highlight the widespread industrial and domestic use of MC.
- To present a compendium of MC poisoning cases.
Main Methods:
- Review of 26 reported cases of methylene chloride poisoning.
- Analysis spanning a 50-year period.
- Compilation of clinical data and outcomes.
Main Results:
- Increased incidence of acute methylene chloride toxicity.
- High prevalence of domestic exposure incidents.
- Central nervous system effects are a common sequela.
- Widespread industrial and domestic use of methylene chloride confirmed.
Conclusions:
- Methylene chloride poisoning is an increasing concern with significant CNS impact.
- Lack of medical experience in diagnosing and treating MC poisoning is evident.
- Clinical experience with MC poisoning necessitates broader awareness and preparedness.