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53BP1: A key player of DNA damage response with critical functions in cancer

Mohammad Mirza-Aghazadeh-Attari1, Amir Mohammadzadeh1, Bahman Yousefi2

  • 1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

DNA Repair
|December 1, 2018
PubMed

Insights

The tumor suppressor P53-binding protein 1 (53BP1) is crucial for DNA repair and genome stability. Its dysfunction contributes to cancer development, progression, and drug resistance, highlighting its importance in cancer research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Genome integrity is maintained by the DNA damage response (DDR) pathway.
  • Disruptions in DDR signaling are linked to various disorders, especially cancer.
  • 53BP1 is a key DDR mediator involved in DNA double-strand break (DSB) repair pathway choice.

Purpose of the Study:

  • To review the structure and function of 53BP1.
  • To elucidate 53BP1's role in cancer initiation, progression, angiogenesis, metastasis, and drug resistance.
  • To highlight 53BP1 as a potential therapeutic target in cancer treatment.

Main Methods:

  • Literature review and synthesis of existing research on 53BP1.
  • Analysis of 53BP1's interactions with other DNA damage-responsive proteins.
  • Examination of the clinical implications of aberrant 53BP1 expression and function in human malignancies.

Main Results:

  • 53BP1 plays a pivotal role in orchestrating DSB repair pathway selection.
  • Aberrant 53BP1 expression and loss of function are associated with tumor occurrence, progression, and poor prognosis.
  • 53BP1 is implicated in critical cancer processes including angiogenesis, metastasis, and drug resistance.

Conclusions:

  • 53BP1 is essential for maintaining genome stability and its dysregulation is a significant factor in cancer development.
  • Understanding 53BP1's structure-function relationship is vital for developing targeted cancer therapies.
  • Targeting 53BP1 holds promise for improving cancer treatment strategies and patient outcomes.
Keywords:
53BP1CancerDNA damage responseDNA repairDouble strand breaks

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