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Evaluation of mean monocyte volume in septicemia caused by Salmonella species

Dilip Kumar1, Madhusoodanan Sudha1, Bansidhar Tarai1

  • 1Department of Microbiology, Institute of Lab Medicine, Max Super Speciality Hospital, New Delhi, India.

Journal of Laboratory Physicians
|December 1, 2018
PubMed
Abstract

Insights

Mean monocyte volume (MMV) is significantly elevated in Salmonella infection. This parameter can help predict Salmonella infections, offering a potential diagnostic aid in clinical settings.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Immunology

Background:

  • Salmonella infections pose a significant global health burden.
  • Accurate and timely diagnosis of Salmonella is crucial for effective treatment.
  • Monocyte characteristics may offer insights into infectious processes.

Purpose of the Study:

  • To investigate the diagnostic utility of monocyte volume, conductivity, and scatter (VCS) parameters in Salmonella infection.
  • To determine if VCS parameters can differentiate Salmonella infections from other infections and normal states.

Main Methods:

  • Analysis of peripheral blood samples from 52 patients with confirmed Salmonella (S. typhi, S. paratyphi A) bloodstream infections.
  • Utilized a Beckman Coulter LH750 hematology analyzer to assess monocyte VCS parameters.
  • Compared monocyte VCS parameters between Salmonella-infected patients and two control groups (other infections, healthy subjects).

Main Results:

  • Mean monocyte volume (MMV) and standard deviation of MMV were significantly increased in Salmonella infection (P < 0.05) compared to both control groups.
  • Standard deviation of mean channel monocyte conductivity also showed significant increases in Salmonella infection.
  • A proposed cutoff value of 185 for MMV demonstrated 80% sensitivity and 73% specificity for predicting Salmonella infection.

Conclusions:

  • Mean monocyte volume (MMV) emerges as a valuable indicator for predicting Salmonella infection.
  • Monocyte VCS parameters, particularly MMV, show potential as a cost-effective diagnostic tool in clinical practice.
  • Further validation in diverse clinical settings is recommended to establish MMV as a reliable biomarker.
Keywords:
Mean monocyte volumeSalmonellamonocytessepticemia

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