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Prevalence of Stroke and Hypoperfusion in Patients With Isolated Vertigo and Vascular Risk Factors

Dao Pei Zhang1,2, Hao Ran Li2, Qian Kun Ma3

  • 1Department of Neurology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.

Frontiers in Neurology
|December 1, 2018
PubMed

Insights

Patients with isolated vertigo and vascular risk factors have a higher prevalence of stroke and cerebellar hypoperfusion. Diabetes mellitus and vertebral artery (VA) issues like stenosis or hypoplasia are key associated risk factors.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Isolated vertigo can be a symptom of underlying cerebrovascular disease.
  • Patients with vascular risk factors require careful evaluation for stroke and hypoperfusion.
  • Understanding the prevalence and risk factors for these conditions in this population is crucial.

Purpose of the Study:

  • To determine the prevalence of stroke and hypoperfusion in patients presenting with isolated vertigo and vascular risk factors.
  • To identify associated factors contributing to stroke and hypoperfusion in this patient group.

Main Methods:

  • 157 patients with isolated vertigo and vascular risk factors underwent multimodal magnetic resonance imaging (MRI).
  • Magnetic resonance angiography (MRA) assessed vertebrobasilar arteries, including length and curvature index of the vertebral artery (VA).
  • Perfusion-weighted imaging (PWI) evaluated cerebral blood flow, blood volume, and transit times to detect regional cerebellar hypoperfusion.

Main Results:

  • The prevalence of stroke was 24.8% in patients with isolated vertigo and vascular risk factors.
  • Cerebellar hypoperfusion was observed in 57.6% of non-stroke patients.
  • Independent risk factors for stroke included diabetes mellitus and VA stenosis or hypoplasia; for hypoperfusion, enlarged VA curvature index and VA stenosis/hypoplasia were significant.

Conclusions:

  • Patients with isolated vertigo and vascular risk factors exhibit a higher incidence of stroke and hypoperfusion.
  • Diabetes mellitus, vertebral artery stenosis or hypoplasia, and increased vertebral artery curvature index are significant risk factors.
  • Multimodal MRI is valuable for diagnosing stroke and hypoperfusion in patients with isolated vertigo.

Keywords:
basilar arteryhypoperfusionstrokevertebral arteryvertigovessel curvature

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