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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
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Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

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[Anemia in the aged].

Gabriele Röhrig1

  • 1Zentrum für spezialisierte geriatrische Diagnostik, MVZ Medicum Köln Ost, Johann-Classen-Str. 68, 51103, Köln, Deutschland. gabriele.roehrig-herzog@mvz-koeln-ost.de.

Zeitschrift Fur Gerontologie Und Geriatrie
|December 1, 2018
PubMed
Summary
This summary is machine-generated.

Anemia in older adults is a significant issue impacting function. Research is clarifying its complex causes and potential classification as a geriatric syndrome.

Keywords:
Blood proteinsErythrocyte indicesHepcidinIron-binding proteinsReference values

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Area of Science:

  • Geriatrics
  • Hematology
  • Internal Medicine

Background:

  • Anemia in the aged is frequently underestimated.
  • Recent research offers deeper insights into anemia in older populations.
  • The multicausality and negative functional impact are key characteristics.

Purpose of the Study:

  • To provide a concise overview of the current research on anemia in the aged.
  • To discuss the potential classification of anemia as a geriatric syndrome.
  • To highlight the clinical relevance of understanding anemia in older individuals.

Main Methods:

  • Literature review of recent research on anemia in the aged.
  • Analysis of studies focusing on the causes and outcomes of anemia in older adults.
  • Synthesis of current scientific discussions regarding anemia as a geriatric syndrome.

Main Results:

  • Anemia in older adults is characterized by multiple causes.
  • Anemia negatively impacts functional outcomes in the elderly.
  • There is an ongoing scientific debate about classifying anemia as a geriatric syndrome.

Conclusions:

  • A differentiated approach to anemia in the aged is now possible due to increased research.
  • Recognizing anemia's impact on function is crucial for geriatric care.
  • Further research may solidify the concept of anemia as a geriatric syndrome.