Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

4.2K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
4.2K
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

9.4K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
9.4K
COP Coated Vesicles00:59

COP Coated Vesicles

18.2K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
18.2K
Coat Assembly and GTPases01:33

Coat Assembly and GTPases

4.4K
Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
4.4K
Epistasis01:39

Epistasis

50.2K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
50.2K
Position-effect Variegation02:32

Position-effect Variegation

7.1K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reflections on a Posthumous Existence.

JAMA cardiology·2023
Same author

My Transcatheter Aortic Valve Replacement.

JAMA cardiology·2022
Same author

The Road Not Taken.

JAMA neurology·2022
Same author

The Stress Test.

The Hastings Center report·2019
Same author

Left atrial appendage.

Pacing and clinical electrophysiology : PACE·2018
Same author

The Lower Seven-Eighths.

JAMA·2017

Related Experiment Video

Updated: Feb 1, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

8.5K

When I Take Off My White Coat….

Joseph Gascho1

  • 1A cardiologist at Penn State College of Medicine in Hershey, Pennsylvania.

AMA Journal of Ethics
|December 1, 2018
PubMed
Summary
This summary is machine-generated.

Physicians engage in diverse personal interests outside of medicine, such as sports, music, and art. These activities can enhance their well-being and potentially improve their clinical practice.

More Related Videos

Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice
09:00

Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice

Published on: January 25, 2021

13.5K
Graphene Coatings for Biomedical Implants
13:21

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

21.8K

Related Experiment Videos

Last Updated: Feb 1, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

8.5K
Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice
09:00

Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice

Published on: January 25, 2021

13.5K
Graphene Coatings for Biomedical Implants
13:21

Graphene Coatings for Biomedical Implants

Published on: March 1, 2013

21.8K

Area of Science:

  • Medical Humanities
  • Physician Well-being

Background:

  • Public perception often portrays physicians as solely dedicated to their professional roles.
  • Physicians, like all individuals, have personal lives and engage in various non-medical activities.

Purpose of the Study:

  • To explore the personal interests and hobbies of physicians outside of their clinical duties.
  • To examine the potential impact of these non-professional activities on physician performance and empathy.

Main Methods:

  • Qualitative exploration of physicians' personal lives and hobbies.
  • Analysis of anecdotal evidence and common physician activities outside of work.

Main Results:

  • Physicians participate in a wide range of activities including pet ownership, sports, music, and art.
  • These personal pursuits are undertaken for personal fulfillment and stress relief, similar to the general population.

Conclusions:

  • Physicians' personal lives and engagement in hobbies are integral to their identity beyond their professional roles.
  • Activities outside of medicine can contribute to a physician's overall well-being, potentially fostering enhanced empathy and patient care.