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Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
Published on: January 19, 2014
[Ocular thrombotic microangiopathy in atypical hemolytic-uremic syndrome (a clinical case study)]
T V Smirnova1, V M Sheludchenko1, N L Kozlovskaya2
1Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.
Abstract:
The article presents a clinical observation of ocular thrombotic microangiopathy in atypical hemolytic-uremic syndrome - a rare genetic disease characterized by systemic thrombosis caused by uncontrolled activation of alternative complement pathway. A typical manifestation of this ocular lesion in this disease is bilateral Purtscher-like retinopathy. Timely diagnostics of atypical hemolytic-uremic syndrome, including ophthalmologic examination, determines the early start of a highly effective pathogenetic therapy with complement inhibitor eculizumab.
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