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Updated: Feb 1, 2026
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Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
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[Wavefront and accommodation parameters under different conditions of correction in myopia and hyperopia]
V V Neroev1, E P Tarutta1, S G Harutyunyan1
1Helmholtz Moscow Research Institute of Eye Diseases, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
Vestnik Oftalmologii
|December 1, 2018
Summary
Soft contact lenses (SCL) alter wavefront aberrations and elevate accommodation in both myopia and hyperopia. The induced negative spherical aberration enhances accommodative response, offering insights for refractive error correction strategies.
Area of Science:
- Ophthalmology
- Optometry
- Vision Science
Background:
- Refractive errors like myopia and hyperopia affect millions globally.
- Understanding how optical corrections influence visual function is crucial for effective management.
- Wavefront aberrations and accommodative responses are key indicators of visual quality.
Purpose of the Study:
- To compare wavefront and accommodation parameters in myopic and hyperopic eyes with and without soft contact lenses (SCL).
- To assess these parameters under both natural and cycloplegic conditions.
- To investigate the impact of SCL on higher-order aberrations and accommodative function.
Main Methods:
- Examined 142 myopic and 48 hyperopic eyes in 95 patients (ages 5-32).
- Measured wavefront aberrations and accommodation parameters (OAR, RAR, PA) with and without SCL, before and after cycloplegia.
- Analyzed higher-order aberrations including RMSHOAs, Trefoil, Coma, and spherical aberration (SA) in a 4 mm zone.
Main Results:
- SCL induced distinct changes in wavefront aberrations for myopia and hyperopia, including shifts in Coma and Trefoil values.
- Spherical aberration (SA) transitioned from positive to negative with SCL wear in both refractive groups.
- Accommodation and pseudo-accommodation amplitude (PA) were significantly higher with SCL compared to glasses.
Conclusions:
- Soft contact lenses modify wavefront aberrations differently in myopia and hyperopia.
- Accommodation and PA are enhanced when using SCL in both myopia and hyperopia.
- The negative spherical aberration induced by SCL positively impacts accommodative response, informing future refractive correction development.
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