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How I investigate Eosinophilia.

Rebecca L Larsen1, Natasha M Savage1

  • 1Medical College of Georgia, Augusta University, Augusta, Georgia.

International Journal of Laboratory Hematology
|December 1, 2018
PubMed
Summary

Persistent eosinophilia requires careful evaluation, correlating clinical history, lab data, and morphology. This review provides practical guidelines for diagnosing eosinophilic disorders, including recent World Health Organization (WHO) updates.

Keywords:
bloodbone marroweosinophilsleukemiamorphologymyeloid

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Area of Science:

  • Hematology
  • Pathology
  • Oncology

Background:

  • Eosinophilia is usually reactive, linked to various neoplastic and non-neoplastic conditions.
  • Clonal eosinophilia presents diagnostic challenges within hematopoietic neoplasms.
  • Accurate diagnosis of eosinophilia necessitates integrating clinical, laboratory, and morphological data.

Purpose of the Study:

  • To review current literature on eosinophilia, incorporating the 2016 World Health Organization (WHO) classification.
  • To provide practical, case-based guidelines for evaluating eosinophilia in routine and complex cases.
  • To offer a systematic approach for pathologists investigating eosinophilia.

Main Methods:

  • Literature review focusing on eosinophilia and World Health Organization (WHO)-defined eosinophilic disorders.
  • Case-based format illustrating diagnostic approaches.
  • Guideline development for evaluating persistent eosinophilia.

Main Results:

  • Persistent eosinophilia evaluation requires a multi-faceted approach.
  • The 2016 WHO update provides updated classifications for eosinophilic disorders.
  • Guidelines are presented for practical investigation of eosinophilia.

Conclusions:

  • A comprehensive evaluation integrating clinical, laboratory, morphological, and ancillary testing is crucial for diagnosing eosinophilia.
  • Pathologists can utilize these practical guidelines for efficient and accurate investigation of eosinophilic conditions.
  • Timely diagnosis of eosinophilia is facilitated by understanding appropriate ancillary testing.