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Published on: February 13, 2011
Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia
Kim Oren Gradel1, Pedro Póvoa1,2,3, Pernille Just Vinholt4
1Center for Clinical Epidemiology, Odense University Hospital, and Research Unit of Clinical Epidemiology, Institute of Clinical Research, University of Southern Denmark, Kløvervænget 30, Entrance 216, ground floor, 5000 Odense C, Denmark.
Aim:
To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.
Patients & Methods:
Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.
Results & Conclusion:
Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.
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