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Published on: April 26, 2012
Hydration requirements in patients receiving highly emetogenic chemotherapy
Randy Erickson1, Neil Nebughr1, Michael C Mosier2
1Utah Cancer Specialists, 1121 East 3900 C-230, Salt Lake City, UT 84124, USA.
Aim:
Chemotherapy-induced nausea and vomiting diminishes quality of life and increases healthcare resource use. This retrospective medical records analysis evaluated hydration requirements with emetogenic chemotherapy.
Patients & Methods:
Cancer patients received moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC), and antiemetics palonosetron or granisetron extended-release subcutaneous (GERSC), neurokinin 1 receptor antagonist and dexamethasone. Unscheduled hydration event rates were determined.
Results:
For 186 patients (92 palonosetron, 94 GERSC) overall, mean hydration rate was significantly higher with palonosetron (0.6 vs 0.2; p = 0.0005). Proportion of patients with ≥1 hydration event was significantly higher with palonosetron overall (54 vs 33%; p = 0.0033) and in cycles 2-4 and the HEC subgroup.
Conclusion:
GERSC within a three-drug antiemetic regimen may reduce unscheduled hydration requirements with MEC or HEC.
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