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Updated: Feb 1, 2026

Interactive Molecular Model Assembly with 3D Printing
Published on: August 13, 2020
Self-complementary hydrogen-bond interactions of guanosine: a hub for constructing supra-amphiphilic polymers with
Qian Xiao1, Fei Song1, Wu-Cheng Nie1
1Center for Degradable and Flame-Retardant Polymeric Materials, College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, Chengdu 610064, China. songfei520@gmail.com.
Abstract:
A supra-amphiphilic polymer (SAP) with controlled molecular structures is constructed, in this work, via self-complementary hydrogen bonding of guanosine groups between a hydrophilic block, poly(N-isopropylacrylamide), and a hydrophobic block, poly(ε-caprolactone). By simply changing the mixing ratio of the guanosine-capped hydrophilic and hydrophobic blocks, a series of SAPs with tailored nanostructures are constructed, which can further self-assemble into different nano-aggregates in solution, including spheres, vesicles and large vesicle micelles. The thermo-induced phase transition of the hydrophilic block induces the fusion and aggregation of the nanoparticles into irregular particles upon heating, which further transform to large compound vesicles after cooling.
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