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Published on: June 21, 2018
Prepregnancy maternal body mass index and venous thromboembolism: a population-based cohort study
A J Butwick1, J Bentley2, S A Leonard3
1Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Objective:
To assess the relation between maternal body mass index (BMI) and pregnancy-related venous thromboembolism (VTE).
Design:
Cohort study.
Setting And Population:
A total of 2 449 133 women with singleton pregnancies who underwent delivery hospitalisation in California between 2008 and 2012.
Methods:
Association of pre-pregnancy BMI and the risk of an antepartum and postpartum VTE was examined using logistic regression, with normal BMI as reference.
Main Outcome Measures:
Antepartum and postpartum VTE-related hospitalisation.
Results:
The prevalence of antepartum and postpartum VTE increased with increasing BMI (antepartum: 2.3, 3.0, 3.8, 4.2, 4.7, and 10.6 per 10 000 women for underweight, normal BMI, overweight, obesity class I, II, and III, respectively, P < 0.001; postpartum: 2.0, 3.1, 3.9, 5.6, 9.0, and 13.2 per 10 000 women, P < 0.01). The adjusted odds of antepartum and postpartum VTE increased progressively with increasing BMI, with obesity class III women having the highest risk of pregnancy-related VTE compared with normal BMI women: adjusted odds ratio for antepartum VTE: 2.9; 95% CI 2.2-3.8 and adjusted odds ratio for postpartum VTE: 3.6; 95% CI 2.9-4.6.
Conclusions:
Our findings clearly demonstrate an increasing risk of pregnancy-related VTE with increasing BMI.
Tweetable Abstract:
Obesity was associated with increased odds of antepartum and postpartum venous thromboembolism.
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