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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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[Growth failure as a symptom of inflammatory bowel disease]

Liselotte C de Kloet1,2, Sebastian E E Schagen1, Anemone van den Berg1

  • 1Juliana Kinderziekenhuis, afd. Kindergeneeskunde, Den Haag.

Nederlands Tijdschrift Voor Geneeskunde
|December 1, 2018
PubMed

Insights

Growth failure in children may indicate undiagnosed inflammatory bowel disease (IBD). Early diagnosis of IBD is crucial to prevent long-term growth impairment and ensure optimal adult height.

Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Inflammatory Bowel Disease

Background:

  • Growth failure is a potential indicator of pediatric inflammatory bowel disease (IBD).
  • Diagnosing IBD can be challenging, especially with nonspecific gastrointestinal symptoms.
  • Delayed diagnosis of IBD is linked to reduced adult height.

Observation:

  • A 15-year-old male presented with growth failure and delayed puberty.
  • Further investigations led to a diagnosis of Crohn's disease.

Findings:

  • Inflammatory bowel disease should be suspected in children with unexplained growth failure and delayed puberty.
  • Thorough gastrointestinal symptom history is essential.
  • Adherence to diagnostic guidelines for short stature is recommended.

Implications:

  • Considering IBD in pediatric growth failure can lead to earlier diagnosis and intervention.
  • Prompt IBD diagnosis helps mitigate negative impacts on long-term growth.
  • This case highlights the importance of a multidisciplinary approach in pediatric endocrinology and gastroenterology.
Abstract

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