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Updated: Feb 1, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Anti-IL17 therapies for psoriasis
Annika Silfvast-Kaiser1, So Yeon Paek1, Alan Menter1
1a Division of Dermatology , Baylor University Medical Center , Dallas , TX , USA.
Expert Opinion on Biological Therapy
|December 1, 2018
Summary
New biologic agents targeting Interleukin-17 (IL-17) inhibitors, including monoclonal antibodies and IL-17 receptor antagonists, offer effective treatments for moderate-to-severe plaque psoriasis. These advancements provide improved therapeutic options for patients with this chronic skin condition.
Area of Science:
- Immunodermatology
- Inflammatory Diseases
- Pharmacology
Background:
- Plaque psoriasis pathogenesis involves the pro-inflammatory cytokine Interleukin-17 (IL-17).
- Traditional treatments have limitations, prompting a shift towards targeted therapies.
- IL-17's role in psoriasis necessitates the development of specific therapeutic agents.
Purpose of the Study:
- To review the clinical efficacy, safety, and tolerability of IL-17 inhibitors for plaque psoriasis.
- To summarize existing literature on approved IL-17 targeting agents.
- To discuss the impact of IL-17 inhibitors on psoriasis treatment paradigms.
Main Methods:
- Literature review of studies on IL-17 inhibitors for plaque psoriasis.
- Summarization of clinical trial data for secukinumab, ixekizumab, and brodalumab.
- Analysis of safety and efficacy profiles from published research via PubMed.
Main Results:
- Secukinumab, ixekizumab (anti-IL-17A), and brodalumab (anti-IL-17 receptor) are approved for moderate-to-severe plaque psoriasis.
- These agents demonstrate significant clinical efficacy in treating plaque psoriasis.
- The safety and tolerability profiles of these IL-17 inhibitors are established through clinical trials.
Conclusions:
- IL-17 inhibitors have expanded treatment options for plaque psoriasis, confirming IL-17's pathogenic role.
- Future biologic treatments for psoriasis will likely involve more specific IL-17 and IL-23 targeting agents.
- The development of targeted therapies represents a significant advancement in managing psoriasis.
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