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Updated: Feb 1, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
Antibacterial activity of a polysaccharide produced from Chaetomium globosum CGMCC 6882
Zichao Wang1, Ronghui Xue1, Jingwen Cui1
1College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.
Abstract:
In present work, a polysaccharide (GCP) was produced by Chaetomium globosum CGMCC 6882 and characterized. GCP was composed of arabinose, galactose, glucose, xylose, mannose and glucuronic acid in a molar ratio of 0.64: 2.58: 23.53: 0.90: 2.47: 0.27 with molecular weight of 8.093 × 104 Da and polydispersity (Mw/Mn) of 1.014. Antibacterial characteristics and mechanism of GCP against Escherichia coli and Staphlococcus aureus were investigated by analysis of inhibition zones, minimum inhibitory concentration (MIC), alkaline phosphatase and β-galactosidase activities, electrical conductivity and bacterial morphology. Results showed that the MIC of GCP against E. coli and S. aureus were 1.75 mg/mL and 0.67 mg/mL, respectively. Moreover, GCP exerted antibacterial activities by disrupting the inner membrane and increasing the cell permeability, but had no influences on cell wall. This work indicated that GCP could be explored as a promising antibacterial agent in food and pharmaceutical industries.
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