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Generation of Tissue Spheroids via a 3D Printed Stamp-Like Device
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Note: A versatile 3D-printed droplet-on-demand generator.

Nikolay Ionkin1, Daniel M Harris1

  • 1School of Engineering, Brown University, Providence, Rhode Island 02912, USA.

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This summary is machine-generated.

A new 3D-printed generator creates precise, single droplets on demand for lab experiments. This versatile device simplifies production and is adaptable for various fluid dynamics research applications.

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Area of Science:

  • Fluid Dynamics
  • Experimental Physics
  • Materials Science

Background:

  • Droplet generation is crucial for experiments like droplet impact.
  • Existing methods can be complex or costly to reproduce.
  • 3D printing offers a pathway to simplified fabrication.

Purpose of the Study:

  • To present a versatile, 3D-printed droplet-on-demand generator.
  • To simplify the manufacturing process of droplet generators.
  • To enable reproducible droplet generation for laboratory use.

Main Methods:

  • 3D printing of principal components based on an existing design.
  • Testing with de-ionized water and water-glycerol mixtures.
  • Characterization of droplet size and variability.

Main Results:

  • Reliable production of single droplets-on-demand with diameters from 0.65-1.32 mm.
  • Achieved overall droplet variability of less than 1%.
  • Demonstrated successful operation with multiple working fluids.

Conclusions:

  • The 3D-printed generator is a versatile and cost-effective tool for droplet experiments.
  • The simplified manufacturing process facilitates wider adoption.
  • Open-access design files promote reproducibility and adaptation.