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Updated: Feb 1, 2026

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
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Published on: October 3, 2019

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Nanoyttria attenuates isoproterenol-induced cardiac injury

Chandraiah Godugu1, Preeti Kumari1, Amit Khurana1

  • 1Department of Regulatory Toxicology, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Telangana State, PIN-500037, India.

Nanomedicine (London, England)
|December 4, 2018
PubMed
Abstract

Insights

Nanoyttria (NY) protects against isoproterenol-induced cardiotoxicity by reducing inflammation and fibrosis. This study shows NY ameliorates cardiac remodeling, offering potential therapeutic benefits for heart conditions.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cardiology

Background:

  • Isoproterenol (ISO) is widely used to induce cardiotoxicity in animal models.
  • Cardiac remodeling is a pathological process that leads to heart failure.
  • Nanomaterials are being explored for their therapeutic potential in cardiovascular diseases.

Purpose of the Study:

  • To investigate the cardioprotective effects of nanoyttria (NY).
  • To evaluate NY's efficacy in mitigating ISO-induced cardiotoxicity and cardiac remodeling.

Main Methods:

  • Nanoyttria (NY) characterization using various techniques.
  • Induction of cardiotoxicity in mice using Isoproterenol (ISO).
  • Treatment of ISO-challenged mice with two doses of NY (0.4 and 4 mg/kg) for 28 days.
  • Assessment of biochemical parameters, proinflammatory cytokines (IL-1β, IL-6, TNF-α), histopathology, ECG, hydroxyproline, and TGF-β1 expression.

Main Results:

  • NY exhibited free radical scavenging activity.
  • NY treatment alleviated ISO-induced cardiotoxicity, reducing key biochemical markers.
  • Significant decrease in proinflammatory cytokines (IL-1β, IL-6, TNF-α) was observed.
  • Histopathology and ECG confirmed protection of cardiac histoarchitecture and rhythm.
  • Reduced hydroxyproline and TGF-β1 expression indicated antifibrotic activity of NY.

Conclusions:

  • Nanoyttria (NY) demonstrates significant cardioprotective effects against ISO-induced cardiotoxicity.
  • NY ameliorates cardiac remodeling by reducing inflammation and fibrosis.
  • This study is the first to report NY's ability to mitigate ISO-induced cardiac remodeling, suggesting its therapeutic potential.
Keywords:
cardiac remodelingfibrosisinflammationnanoyttriaoxidative stress

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