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Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact
1Intelligent Insect Control, Montpellier, France. Ole.Skovmand@insectcontrol.net.
Malaria Journal
|December 4, 2018
Summary
Insecticide resistance in malaria control is a concern. A study found that while PBO-treated nets showed higher efficacy, this may be due to more permethrin, not the PBO synergist.
Area of Science:
- Medical Entomology
- Public Health
- Vector Control
Background:
- Insecticide resistance poses a significant threat to malaria control efforts.
- Piperonyl butoxide (PBO) is an insecticide synergist explored for use in bed nets to combat resistance.
Purpose of the Study:
- To compare the efficacy of insecticide-treated nets with and without PBO in Tanzania.
- To evaluate the contribution of PBO to the effectiveness of pyrethroid-treated bed nets.
Main Methods:
- A high-quality randomized cluster trial was conducted in Tanzania.
- Malaria prevalence was compared between users of Olyset nets (permethrin only) and Olyset Plus nets (permethrin + PBO).
Main Results:
- Olyset Plus nets expose significantly more permethrin on the surface compared to Olyset nets.
- The superior efficacy observed with Olyset Plus may be attributed to higher permethrin levels, not necessarily the PBO synergist.
Conclusions:
- The effectiveness of Olyset Plus nets might be primarily due to increased permethrin availability.
- Current evidence, including this study and WHO evaluations, suggests caution in attributing superior effects solely to PBO.
- Further research is needed before policy changes are made regarding "PBO nets".
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