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Updated: Feb 1, 2026
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
[Clinical Significance of Additional Chromosomal 8 Clonal Evolution in CML Progression]
Ou Ji1, Guang-Rong Zhu2, Lin Lin2
1Department of Hematology, Affiliated Hospital; Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Pro- vince, China. First Clinical Medical College; Nanjing University of Traditional Chinese Medicine, Nanjing 210046, Jiangsu Province, China.
Objectives:
To explore the clinical significance of clonal evolution of additional chromosomal 8 in CML progression.
Methods:
An unusual case with the clonal evolution from trisomy 8 to tetrasomy 8 accompanied by 2 time of CML blast crisis (BC) was reported.
Results:
This patient suffered from 2 time of CML blast crisis and the additional chromosome 8 aberrations were accompanied. Trisomy 8 and tetrasomy 8 were detected at first CML blast crisis and second CML blast crisis, respectively. After tetrasomy 8 was developed, the c-Myc was over-expressed and the central nervous system leukemia happened in this case. Only high dose Ara-C and MTX regimen could induce remission for a short period.
Conclusion:
These findings suggested that additional chromosome 8 aberrations are important marker for poor prognosis of CML patients and contribute to a poor prognosis.
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