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Updated: Feb 1, 2026

Programmed Electrical Stimulation in Mice
Published on: May 26, 2010
Mirth and laughter induced by electrical stimulation of the posterior insula
1Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Abstract:
Laughter induced in the insula is uncommon. In this case-report we present a description of a patient with drug-resistant focal epilepsy for whom laughter with mirth was elicited when the posterior insula (PI) was stimulated by intracranial electrodes. We attempted to analyze the progression of laughter in the insula and suggest a possible pathway for the expression of laughter.
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