Related Experiment Video
Updated: Feb 1, 2026

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
Published on: September 22, 2023
Infection control influence of Middle East respiratory syndrome coronavirus: A hospital-based analysis
Jaffar A Al-Tawfiq1, Rana Abdrabalnabi2, Alla Taher2
1Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of Medicine, Indianapolis, IN, USA; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background:
Middle East respiratory syndrome coronavirus (MERS-CoV) caused multiple outbreaks. Such outbreaks increase economic and infection control burdens. We studied the infection control influence of MERS-CoV using a hospital-based analysis.
Methods:
Our hospital had 17 positive and 82 negative cases of MERS-CoV between April 1, 2013, and June 3, 2013. The study evaluated the impact of these cases on the use of gloves, surgical masks, N95 respirators, alcohol-based hand sanitizer, and soap, as well as hand hygiene compliance rates.
Results:
During the study, the use of personal protective equipment during MERS-CoV compared with theperiod before MERS-CoV increased dramatically from 2,947.4 to 10,283.9 per 1,000 patient-days (P<.0000001) for surgical masks and from 22 to 232 per 1,000 patient-days (P <.0000001) for N95 masks. The use of alcohol-based hand sanitizer and soap showed a significant increase in utilized amount (P<.0000001). Hand hygiene compliance rates increased from 73% just before the occurrence of the first MERS case to 88% during MERS cases (P = .0001). The monthly added cost was $16,400 for included infection control items.
Conclusions:
There was a significant increase in the utilization of surgical masks, respirators, soap and alcohol-based hand sanitizers. Such an increase is a challenge and adds cost to the healthcare system.
Insights
Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks significantly increased personal protective equipment use and hand hygiene compliance. However, this surge in infection control measures also substantially raised healthcare system costs.
Area of Science:
- Infectious Diseases
- Epidemiology
- Healthcare Management
Background:
- Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose significant economic and infection control challenges.
- Hospital-based analyses are crucial for understanding the impact of emerging infectious diseases.
Purpose of the Study:
- To evaluate the infection control influence of MERS-CoV cases within a hospital setting.
- To assess the impact of MERS-CoV on the utilization of personal protective equipment (PPE) and hand hygiene practices.
Main Methods:
- A hospital-based study analyzed 17 MERS-CoV positive and 82 negative cases.
- Evaluated changes in the use of gloves, surgical masks, N95 respirators, alcohol-based hand sanitizer, and soap.
- Assessed hand hygiene compliance rates before and during MERS-CoV cases.
Main Results:
- Utilization of surgical masks and N95 respirators increased dramatically (P<.0000001).
- Significant increases observed in the use of alcohol-based hand sanitizer and soap (P<.0000001).
- Hand hygiene compliance rose from 73% to 88% (P=.0001), with an added monthly cost of $16,400 for infection control items.
Conclusions:
- MERS-CoV outbreaks led to a significant increase in the use of essential infection control supplies.
- The heightened demand for PPE and hygiene products presents a substantial financial challenge for healthcare systems.
- Effective infection control during outbreaks requires careful consideration of resource allocation and cost-effectiveness.
Related Concept Videos
Hospitals-II
Nurses that work in...
Hospitals-I
Respiratory Regulation of Acid-Base Balance
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
Anatomy of Respiratory System II: Lower Respiratory Tract
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Respiratory System
Anatomy of Respiratory System I: Upper Respiratory Tract
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....

